Atletico Madrid won the first leg 1-0 over Liverpool in Spain but the Reds are the reigning European champions and runaway Premier League leaders for a reason.
Henderson returns from a hamstring injury to boost the Reds, although boss Jurgen Klopp was reserved on whether he’d start.
“Hendo is ready but what we do with that, I don’t know or maybe I know and I don’t say,” Klopp said.
Goalkeeper Alisson Becker is out with a hip problem so Adrian will deputise again, while Andy Robertson will return after missing the weekend’s 2-1 win over Bournemouth for precautionary reasons.
Atletico will also be bolstered by the return of Portuguese forward Joao Felix who missed the first leg in Madrid.
“Joao is a super player, wow, young and so skilled it’s a really nice combination,” Klopp said.
“I heard Morata is a slight doubt but Joao Felix is now in. We saw the last game and it looked like it was really intense for him after a long break.
“The game tomorrow night will be intense for him as well. We have to keep them busy in areas where they don’t want to be busy, especially for the offensive players.
“But I know the speed he has, the creativity he has, the football brain he has it can cause us problems if we are not aware of these things.”
Klopp added his side needs to produce more shots on target in the second leg to reverse their fortunes.