Sancho is part of the England squad for the ongoing Euro 2020 finals.
However, the Borussia Dortmund winger has yet to make an appearance for the Three Lions in the European Championship.
England will take on the Czech Republic in their final group game on Tuesday evening.
Ben Chilwell and Mason Mount will not play for the Three Lions, as the Chelsea duo are self-isolating.
Former Manchester United and England international central defender Ferdinand has explained why Southgate needs to give Sancho a chance.
The 21-year-old winger scored eight goals and gave 11 assists in the Bundesliga for Dortmund last season.
The former Manchester City winger scored two goals and provided three assists in the Champions League.
Ferdinand said on his YouTube channel, as transcribed by The Mirror: “There’s inexperienced players that haven’t been to tournaments, they’re everywhere You go on what they’ve done at their club and the last three years, in terms of output, Sancho has been the second best player in terms of goal involvement over the last three years - and he’s done it at Dortmund.
“So to think that you’re talking about experience… he’s played more games than [Phil] Foden at the top level as well as [Mason] Mount and [Jude] Bellingham.
“I just feel that sometimes as a manager you’ve got to be brave. You’ve got to be brave and don’t err on the side of caution.
“In Southgate’s own mind he’s going to have to be brave because I think naturally he’s a more conservative person.
“In his own mind he’ll think he’s being brave when we’re sitting here going, ‘Just play him!’, because we’ve seen him play at the top level.
“But if you’re sitting there as Gareth Southgate, you’ve got to go against your natural instinct.”