The former Premier League champions will take on Sevilla away from home in Spain in Group E.
Lampard has said that the 20-year-old winger will be in the Blues’ starting lineup at Estadio Ramon Sanchez-Pizjuan.
The former England international has said that he has spoken to Hudson-Odoi about his lack of playing time so far this season.
The winger has made one start and four substitute appearances in the Premier League for Chelsea so far this season, scoring one goal in the process.
The England international has also made two starts and two substitute appearances in the Champions League for the London club this campaign, scoring two goals in the process.
During the 2019-20 campaign, Hudson-Odoi made seven starts and 15 substitute appearances in the Premier League and made two starts and three substitute appearances in the Champions League for Chelsea.
Lampard told Chelsea’s official website: “It was difficult, and I have been really pleased with his training lately. I have spoken about Callum at different times since I have been in the job and his work-ethic in training and attitude at the minute is bang on.
“That is reflected in his scoring against Rennes and playing well. He came on against Newcastle and he was bright, he went away with England Under-21s and did well.
“When we have a fully fit squad, as we pretty much do now, I have tough decisions when to leave out players who work hard through the week and are desperate to play for the club, but I have to make that decision. So I did speak to Callum personally as I wanted him to understand where he is at the moment which is on a progression which is getting better for me.
“I want to see more of the same and keep that progression going. If there are times he is not starting or out of the squad, the main thing is I want him to stay positive, and that is part of my job to have that communication level. There are times when other players will have to sit out, and that conversation will have to be with other players.”
Lampard added: “It is not an easy conversation, all players want to play, I expect that, and he will get his opportunity, he will get minutes tomorrow. It is up to him then to keep showing when he plays that he deserves to start, because there is competition in that area, that is the reality of playing for Chelsea.”
Chelsea are at the top of Champions League Group E at the moment with 10 points from four matches, level on points with second-placed Sevilla.
Both Chelsea and Sevilla have booked their place in the last-16 stage of Europe’s premier club competition.